As a high-performance bio-based material, nanocellulose shows broad application prospects in the fields of energy, environmental protection, biomedicine and other fields due to its unique nanostructure, excellent mechanical properties and degradability. Among the many preparation methods, the TEMPO oxidation method has become the mainstream technology for the preparation of carboxylated nanocellulose (TOCN) due to its high selectivity, mild reaction conditions and product stability. This article will systematically explain the technical points of preparing nanocellulose by TEMPO oxidation from the aspects of reaction principle, process flow, performance control and industrialization challenges. 1. Reaction principle of TEMPO oxidation method The core of TEMPO oxidation method is to use 2,2,6,6-tetramethylpiperidine nitroxide radical (TEMPO) as a catalyst, under the synergistic effect of sodium hypochlorite (NaClO) and sodium bromide (NaBr), to selectively oxidize the primary hydroxyl group (-CH₂OH) at the C6 position of the cellulose molecular chain, and convert it into

Today, as the biopharmaceutical industry accelerates its transformation to green, safe and efficient, nanocellulose is moving from the laboratory to the forefront of industrialization due to its natural renewable, excellent biocompatibility, complete degradability and other characteristics, becoming a key material to promote innovation in the medical and health field. As a company deeply involved in the field of nanomaterials, we are driven by technological innovation, focus on the biomedical track, and continue to explore the breakthrough applications of nanocellulose in drug delivery, tissue engineering, medical dressings and other fields to provide safer and more efficient solutions for clinical treatment. 1. Nanocellulose: the 'ideal carrier' for biomedicine. Traditional drug delivery systems often face challenges such as low absorption efficiency, poor targeting, and high toxic and side effects. Nanocellulose has become a high-quality carrier for drug delivery due to its unique physical and chemical properties. Its high specific surface area (up to 1000-5000 m²/g) and abundant hydroxyl groups on the surface can be used to chemically modify negative

With the rapid development of precision medicine and regenerative medicine and the increasing consumer demand for safe medical aesthetics and green medical materials, pain points such as biological rejection and residual toxicity of traditional medical materials have become prominent. Nanocellulose (Nanocellulose), which is biocompatible, degradable and high-performance, has become the core choice for the upgrading of biomedicine and medical aesthetics industries. It is used in fields such as wound repair and drug delivery. As a high-tech enterprise deeply involved in the research, development, production and application of nanocellulose, Nanjing Tianlu Nano Technology Co., Ltd. (hereinafter referred to as 'Nanjing Tianlu Nano'), relying on mature technology and large-scale production capacity, is promoting the industrialization of this green nanomaterial in the fields of biomedicine and medical aesthetics, assisting the high-quality upgrade of the industry, and practicing the development concept of 'green empowerment, technology-driven'. Nanocellulose is mainly divided into CNF cellulose nanofibrils, CNC cellulose nanocrystals, and BNC bacterial nanocellulose. The raw materials come from