TEMPO (2,2,6,6-Tetramethylpiperidine-1-oxyl) oxidation method used to prepare nanocellulose has many advantages, such as mild reaction conditions and high selective oxidation. However, it also has some disadvantages: 1. High cost: The cost of oxidants such as TEMPO and sodium hypochlorite (NaClO) is high, which limits large-scale industrial applications. 2. Environmental issues: Sodium hypochlorite and potassium hypochlorite used in the reaction are strong oxidants, which may cause pollution to the environment and require proper treatment of wastewater and by-products. 3. Complex control of reaction conditions: The reaction conditions of TEMPO oxidation method (such as pH, temperature, oxidant concentration, etc.) need to be strictly controlled, otherwise it may lead to excessive oxidation or insufficient oxidation of cellulose, thereby affecting the quality of the final product. 4. Long reaction time: In some cases, the TEMPO oxidation process may require
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