How much is the residue of TEMPO in TOCNF?

The residual amount of TEMPO (2,2,6,6-tetramethylpiperidine oxide) in Neutralize. To obtain high purity TOCNF, sufficient washing and separation steps are used in the production process to remove residual TEMPO and other reaction by-products (such as sodium bromate and by-product oxidants).TEMPO oxidized cellulose nanofibers (TOCNF) is usually very low because TEMPO is usually removed thoroughly during production or

Control of TEMPO residues

When preparing in industrial production and laboratories TOCNF , the residue of TEMPO is usually controlled by the following methods:

1. Multiple water washing and ultrafiltration : Multiple water washing can effectively remove residual TEMPO and reaction by-products, such as sodium bromate and sodium bromide. Separation techniques such as ultrafiltration can further reduce the content of organic matter and small molecules in the solution.

2. Neutralization and chemical reduction : In some processes, TEMPO is reduced to an inactive form by chemical reduction or the addition of antioxidants, and then separated.

Residue range

According to literature reports and industrial specifications, fully purified the residual amount of TEMPO in TOCNF is usually at the ppm level (<10 ppm) , and can be even lower. This depends on the sensitivity of the purification method and detection method used. Typically, specifications require that the residual amount of TEMPO should be low enough to ensure the safety and non-toxicity of the product.

Detection method

The detection of TEMPO residues usually uses high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and other high-sensitivity analysis technologies to ensure that the purity of TOCNF products meets relevant requirements.