Research on the molecular design, release mechanism and clinical transformation of nanocellulose-based drug sustained release carrier 1. Structural characteristics of nanocellulose and the molecular basis of drug loading 1.1 The crystal structure of nanocellulose and the drug-carrying ability of surface chemical nanocellulose is closely related to its crystal structure and surface chemical groups: cellulose Iβ crystal form (mainly present in plant-source nanocellulose): has a highly ordered hydrogen bond network, suitable for physical adsorption of drug molecules amorphous regions (accounting for 30-50% of cellulose nanofibers): can be used as a reservoir for drug embedding, and increase drug loading volume. Surface functional groups: hydroxyl group: can be covalently connected by esterification and etherification reaction (introduced by TEMPO oxidation): enhance water solubility and use it to release sulfate groups (acid hydrolysis residue): load cationic drugs through electrostatic action Table 1: Comparison of physical and chemical properties of different nanocelluloses Cellulose nanocrystalline cellulose nanofiber nanofiber nanofiber nanofiber nanonitrogen nanonitrogen nanofiber nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitrogen nanonitro

Recently, my country's scientific research team has made important progress in the field of nanocellulose thermal performance research, and has successfully improved the thermal stability and thermal conductivity of nanocellulose through chemical modification and composite technology, opening up a new path for its application in high-temperature environments. This breakthrough is expected to accelerate the innovative development of green materials and promote the transformation of multiple industries toward environmental protection and sustainable directions. Breakthrough Progress: High temperature resistance and high thermal conductivity nanocellulose are introduced. As a renewable bio-based material, nanocellulose has the advantages of lightweight, high strength and degradability, but its insufficient thermal stability (the traditional decomposition temperature is less than 300°C) limits its application in the field of high temperature. In this study, scientists successfully increased the thermal decomposition temperature of nanocellulose to above 350°C through surface chemical modification (such as phosphorylation, silanization) and nanocomposite technology (combined with graphene, boron nitride and other materials), and optimized its thermal conductivity to make it in electronic and construction

1. Overview TEMPO oxidation method is a highly efficient and highly selective nanocellulose preparation technology, which is widely used in the preparation of carboxylated nanocellulose (TOCN). By selective oxidation of the primary hydroxy group at C6 position in natural cellulose molecules, carboxyl functional groups are introduced, so that cellulose has better dispersibility, reactive activity and application functions. 2. Raw materials and pretreatment materials: Pretreatment steps for natural cellulose such as wood pulp, cotton pulp, bamboo pulp, agricultural waste: bleach and remove lignin, improve purity and reaction efficiency, weigh it after drying, prepare reaction 3. Oxidation reaction process parameters (take 1 gram of dry cellulose as an example) The amount of components is used as TEMPO0.016 g (0.1 mmol) catalyst, and start the free radical reaction NaBr0.1 g (1 mmol) synergistic catalysis to improve reaction efficiency N